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Bioorg Med Chem Lett. 1998 Dec 15;8(24):3589-94.

Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor.

Author information

1
Department of Chemistry, University of Illinois, Urbana 61801, USA.

Abstract

A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

PMID:
9934476
DOI:
10.1016/s0960-894x(98)00652-0
[Indexed for MEDLINE]

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