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Clin Exp Immunol. 1999 Feb;115(2):324-8.

Apoptosis of Th1-like cells in experimental tuberculosis (TB).

Author information

1
National Centre for Cell Sciences, Ganeshkhind, Pune 411007, India.

Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-gamma) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

PMID:
9933460
PMCID:
PMC1905165
DOI:
10.1046/j.1365-2249.1999.00755.x
[Indexed for MEDLINE]
Free PMC Article

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