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Clin Exp Immunol. 1999 Jan;115(1):26-31.

Effects of bucillamine and N-acetyl-L-cysteine on cytokine production and collagen-induced arthritis (CIA).

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1
Discovery Research Division, Santen Pharmaceutical Co., Ltd, Osaka, Japan.

Abstract

We investigated the effects of bucillamine and N-acetyl-L-cysteine (NAC) on cytokine production and CIA. Bucillamine and NAC inhibited NF-kappaB activation and tumour necrosis factor-alpha (TNF-alpha) mRNA expression in human monocytic leukaemia cell line THP-1, and cytokine production from monocyte cell lines at concentrations >10-3 M. They also inhibited cytokine production and CIA in mice at a dose of 500 mg/kg. These results suggest that NF-kappaB inhibitors such as bucillamine and NAC may inhibit cytokine-related diseases, including arthritis.

PMID:
9933417
PMCID:
PMC1905176
[Indexed for MEDLINE]
Free PMC Article
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