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J Bioenerg Biomembr. 1998 Oct;30(5):419-29.

Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore?

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Institut de Biochimie et de Génétique Cellulaire de Centre National de la Recherche Scientifique, Université Victor Ségalen-Bordeaux, France.


Large and unselective permeabilities through the inner membrane of yeast mitochondria have been observed for more than 20 years, but the characterization of these permeabilities, leading to hypothesize the existence of a large-conductance unselective channel in yeast inner mitochondrial membrane, was done only recently by several groups. This channel has been tentatively identified as a yeast counterpart to the mammalian permeability transition pore, the crucial role of which is now well-documented in physiopathological phenomena, such as Ca2+ homeostasis, ischemic damages, or programmed cell death. The aim of this review is to make a point on the known characteristics of this yeast mitochondrial unselective channel (YMUC) and to analyze whether or not it can be considered as a "yeast permeability transition pore."

[Indexed for MEDLINE]

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