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Nat Med. 1999 Feb;5(2):170-5.

Identification of autoantibodies associated with myelin damage in multiple sclerosis.

Author information

1
Department of Neurology, University of California, San Francisco 94143-0435, USA. claudeg@itsa.ucsf.edu

Abstract

The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin antigens and high-resolution microscopy, techniques that can detect antigen-specific antibodies in situ, we have identified autoantibodies specific for the central nervous system myelin antigen myelin/oligodendrocyte glycoprotein. These autoantibodies were specifically bound to disintegrating myelin around axons in lesions of acute multiple sclerosis and the marmoset model of allergic encephalomyelitis. These findings represent direct evidence that autoantibodies against a specific myelin protein mediate target membrane damage in central nervous system demyelinating disease.

PMID:
9930864
DOI:
10.1038/5532
[Indexed for MEDLINE]

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