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J Neurochem. 1999 Feb;72(2):734-40.

F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease.

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Centre for Clinical Pharmacology and Therapeutic Toxicology, Department of Medicine, University College, London, England.


F2-isoprostanes are prostaglandin-like compounds derived from free radical-catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F3-isoprostanes, whereas peroxidation of docosahexaenoic acid would give F4-isoprostanes. This study demonstrates the presence of esterified F4-isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F4-isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.

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