Send to

Choose Destination
See comment in PubMed Commons below
Development. 1999 Feb;126(5):975-85.

Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial.

Author information

  • 1Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.


Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We propose that a short-range signal originating from the core of the D/V boundary cells is responsible for activating EGFR in a zone of organizing cells on the edges of the D/V boundary. Using loss-of-function mutations and ectopic expression studies, we show that EGFR signaling is essential for vestigial transcription in these cells and for making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center