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Exp Cell Res. 1999 Feb 1;246(2):249-62.

Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression.

Author information

1
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR, Scotland, United Kingdom.

Abstract

The centromere is a specialized region of the eukaryotic chromosome that is responsible for directing chromosome movements in mitosis and for coordinating the progression of mitotic events at the crucial transition between metaphase and anaphase. In this review, we will focus on recent advances in the understanding of centromere composition at the protein and DNA level and of the role of centromeres in sister-chromatid cohesion and mitotic checkpoint control.

PMID:
9925740
DOI:
10.1006/excr.1998.4278
[Indexed for MEDLINE]

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