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Br J Ophthalmol. 1998 Nov;82(11):1306-8.

Azithromycin for ocular toxoplasmosis.

Author information

1
Department of Ophthalmology, FC Donders Institute, Academic Hospital Utrecht, Netherlands.

Abstract

AIMS:

To investigate the efficacy of azithromycin in patients with ocular toxoplasmosis.

METHODS:

11 immunocompetent patients with ocular toxoplasmosis were treated with azithromycin (500 mg the first day, followed by 250 mg/day for 5 weeks). Ocular and systemic examinations were performed during active retinitis episodes and all patients were followed for at least 1 year.

RESULTS:

The intraocular inflammation disappeared within 4 weeks in seven patients, including two cases with progressive retinitis despite previous treatment with pyrimethamine, sulphadiazine, and folinic acid. Recurrence of retinitis occurred in three patients (27%) within the first year of follow up. No systemic side effects of azithromycin were encountered.

CONCLUSION:

These results indicate that although azithromycin cannot prevent recurrent disease it may be an effective alternative for patients with ocular toxoplasmosis who cannot tolerate standard therapies.

PMID:
9924338
PMCID:
PMC1722414
DOI:
10.1136/bjo.82.11.1306
[Indexed for MEDLINE]
Free PMC Article

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