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Science. 1999 Jan 29;283(5402):676-9.

Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.

Author information

1
Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. an.

Abstract

The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.

PMID:
9924025
DOI:
10.1126/science.283.5402.676
[Indexed for MEDLINE]
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