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J Am Acad Dermatol. 1999 Jan;40(1):27-34.

Skin cancer in Australian heart transplant recipients.

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1
Skin and Cancer Foundation, Darlinghurst, NSW, Australia.

Abstract

BACKGROUND:

Cutaneous malignancy is a major cause of morbidity in organ transplant recipients.

OBJECTIVE:

Our purpose was to report on skin cancer in Australian heart transplant recipients with analysis of HLA factors.

METHODS:

We reviewed histologically proven skin cancers in the first 455 patients undergoing organ transplantation in Sydney, Australia.

RESULTS:

The cumulative incidence of skin cancer was 31% at 5 years and 43% at 10 years with a squamous cell carcinoma/basal cell carcinoma ratio of 3:1. Caucasian origin, increasing age at transplantation, and duration of follow-up were significantly associated with skin cancer. Skin cancer accounted for 27% of 41 deaths occurring after the fourth year. Recipient HLA-DR homozygosity was associated with skin cancer overall, whereas HLA-DR7 was a protective factor in skin cancer overall, squamous cell carcinoma, and Bowen's disease. HLA-A1 and HLA-A11 were significant protective factors in Bowen's disease.

CONCLUSION:

Skin cancer is a major cause of morbidity and long-term mortality in heart transplant patients.

PMID:
9922009
[Indexed for MEDLINE]
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