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Biochim Biophys Acta. 1998 Dec 10;1448(2):183-9.

Calmodulin-dependent protein kinase IV: regulation of function and expression.

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  • 1Institute of Biochemistry III, Swiss Federal Institute of Technology (ETH), Z├╝rich.


Calmodulin-dependent protein kinase IV (CaMKIV) is a key mediator of Ca2+-induced gene expression. This serine/threonine kinase is itself activated by a calmodulin kinase kinase. In the present contribution the gene structure, regulation of activity, the role in Ca2+-dependent gene expression, and the hormonal induction and controlled expression of CaMKIV during tissue development are reviewed.

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