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FEMS Microbiol Lett. 1999 Jan 1;170(1):97-103.

Genetic analysis of the cap5 locus of Staphylococcus aureus.

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Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College, Dublin, Ireland.


Staphylococcus aureus expresses at least eight distinct serotypes of capsular polysaccharide (CP). Gene clusters involved in the expression of serotypes 1, 5 and 8 have been cloned and sequenced. In this report we describe the isolation and analysis of serotype 5 capsular polysaccharide-defective mutants. A naturally occurring cap mutation in the laboratory strains 8325-4 and RN4220 was mapped to the cap5E gene by genetic complementation. The cap5H-K genes were shown to be responsible for CP5 serotype specificity by transduction and complementation.

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