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Methods Enzymol. 1999;301:513-22.

In vitro system to study role of blood flow on nitric oxide production and cell signaling in endothelial cells.

Author information

1
Department of Pathology, University of Alabama, Birmingham 35294, USA.

Abstract

Through the approaches illustrated in this article we have demonstrated how molecular signaling events can be elucidated in cells responding to physiological forces. With the recent findings that endothelial form of nitric oxide synthase is associated with proteins such as caveolin and the availability of these cDNA constructs, this methodology allows a possible avenue to determine the physiological significance of such associations and the regulation of NO formation in response to shear stress.

PMID:
9919599
DOI:
10.1016/s0076-6879(99)01114-3
[Indexed for MEDLINE]

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