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Am J Hum Genet. 1999 Jan;64(1):259-67.

Combined linkage and association sib-pair analysis for quantitative traits.

Author information

1
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309-0447, USA.

Abstract

An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.

PMID:
9915965
PMCID:
PMC1377724
DOI:
10.1086/302193
[Indexed for MEDLINE]
Free PMC Article

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