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Arch Phys Med Rehabil. 1999 Jan;80(1):112-4.

Stroke patients: do they have a predilection for extrapyramidal side effects from amiodarone?

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  • 1Department of Rehabilitation Medicine, Prince Henry Hospital, Little Bay, NSW, Australia.


This report describes two patients with recent stroke who, upon transfer to the rehabilitation medicine service, were noted to have extrapyramidal features. Both patients were receiving amiodarone for management of atrial fibrillation. When this medication was discontinued, there was slow resolution of extrapyramidal features and an improvement in function. Physicians managing acute stroke patients should be alert for features of amiodarone neurotoxicity, because these side effects may occur more readily in patients with recent neurologic impairment and may impede their progress in rehabilitation.

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