Format

Send to

Choose Destination
Biofactors. 1998;8(3-4):273-81.

The mitochondrial permeability transition.

Author information

1
CNR Unit for the Study of Biomembranes, University of Padova Medical School, Italy. bernardi@civ.bio.unipd.it

Abstract

This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A-sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.

PMID:
9914829
DOI:
10.1002/biof.5520080315
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center