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Curr Opin Struct Biol. 1998 Dec;8(6):799-809.

Conformational changes and disease--serpins, prions and Alzheimer's.

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  • 1Department of Haematology Cambridge Institute for Medical Research University of Cambridge Hills Road Cambridge CB2 2XY UK. rwc 1000@cam.ac.uk

Abstract

Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.

PMID:
9914261
[PubMed - indexed for MEDLINE]
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