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Curr Opin Struct Biol. 1998 Dec;8(6):730-7.

Messages from ultrahigh resolution crystal structures.

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1
Laboratoire d'Architecture et Fonction de Macromolécules Biologiques (AFMB) CNRS-UPR9039, IBSM 31 Chemin Joseph-Aiguier 13402 Marseille cedex 20 France.

Abstract

The ever growing availability of macromolecular crystal structures determined at atomic resolution has now reached a critical size, making it possible to obtain statistically unbiased data on both protein stereochemistry and the validity of the parameters used in their refinement. Besides the determination of the precise geometry of proteins and their active sites, high resolution structures have made it possible to check the application of normal mode calculations, to calculate charge density distributions and to analyze hydration shells around protein molecules. Even if only a few structures involve protein complexes, either with ligands or prosthetic groups, the information obtained in these cases is of great interest for obtaining the physical parameters of these interactions.

PMID:
9914254
[Indexed for MEDLINE]
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