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Curr Opin Neurobiol. 1998 Dec;8(6):753-61.

Visuomotor transformations: early cortical mechanisms of reaching.

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Istituto di Fisiologia umana, Universit√° di Roma 'la Sapienza', piazzale Aldo Moro 5, 00185 Rome, Italy.


Recent studies of visually guided reaching in monkeys support the hypothesis that the visuomotor transformations underlying arm movements to spatial targets involve a parallel mechanism that simultaneously engages functionally related frontal and parietal areas linked by reciprocal cortico-cortical connections. The neurons in these areas possess similar combinations of response properties. The multimodal combinatorial properties of these neurons and the gradient architecture of the parietofrontal network emerge as a potential substrate to link the different sensory and motor signals that arise during reaching behavior into common hybrid reference frames. This convergent combinatorial process is evident at early stages of visual information processing in the occipito-parietal cortex, suggesting the existence of re-entrant motor influences on cortical areas once believed to have only visual functions.

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