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Curr Opin Immunol. 1998 Dec;10(6):677-81.

The role of MHC class II molecules in susceptibility and resistance to autoimmunity.

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Departments of Microbiology and Immunology, and of Medicine Stanford University School of Medicine Stanford CA 94305-5402 USA. hughmcd@leland.Stanford.EDU


The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases, be due to negative selection of diabetogenic T cell receptors and, in other cases, to positive selection of other T cells with a suppressive action on the diabetic process. Progress towards understanding the mechanisms of susceptibility continues to lag.

[Indexed for MEDLINE]

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