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Curr Opin Immunol. 1998 Dec;10(6):649-55.

Control of immune pathology by regulatory T cells.

Author information

1
MRC Cellular Immunology Unit Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE UK. Don.Mason@path.ox.ac.uk

Abstract

There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.

PMID:
9914214
[Indexed for MEDLINE]

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