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Curr Opin Immunol. 1998 Dec;10(6):649-55.

Control of immune pathology by regulatory T cells.

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MRC Cellular Immunology Unit Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE UK.


There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.

[Indexed for MEDLINE]

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