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Curr Opin Cell Biol. 1998 Dec;10(6):742-8.

Emerging mechanisms of eukaryotic DNA replication initiation.

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Department of Molecular Genetics and Microbiology Life Science Room 130 State University of New York Stony Brook NY 11794-5222 USA.


Recent research has focused on proteins important for early steps in replication in eukaryotes, and particularly on Cdc6/Cdc18, the MCMs, and Cdc45. Although it is still unclear exactly what role these proteins play, it is possible that they are analogous to initiation proteins in prokaryotes. One specific model is that MCMs form a hexameric helicase at replication forks, and Cdc6/Cdc18 acts as a 'clamp-loader' required to lock the MCMs around DNA. The MCMs appear to be the target of Cdc7-Dbf4 kinase acting at individual replication origins. Finally, Cdc45 interacts with MCMs and may shed light on how cyclin-dependent kinases activate DNA replication.

[Indexed for MEDLINE]

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