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Curr Opin Cell Biol. 1998 Dec;10(6):687-93.

The self-renewing mechanism of stem cells in the germline.

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Department of Cell Biology Box 3709 Duke University Medical Center Durham NC 27710.


Germline stem cells (GSCs) are a self-renewing population of germ cells that serve as the source of gametes in diverse organisms. Current research suggests that the self-renewing division of GSCs is controlled both by somatic signaling and by intracellular mechanisms such as differential gene expression, asymmetric cytoskeletal organization, and the cell cycle machinery. These findings provide a framework for the further study of GSCs and stem cell renewal in general.

[Indexed for MEDLINE]

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