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Curr Opin Cell Biol. 1998 Dec;10(6):710-5.

Liver stem cells: a two compartment system.

Author information

1
Histopathology Department Division of Investigative Science Imperial College School of Medicine at Hammersmith Campus Du Cane Road London W12 ONN UK. malison@rpms.ac.uk

Abstract

Hepatocytes and biliary epithelia are phenotypically very dissimilar, but share a common ancestry. Hepatocytes regenerate very efficiently, and their division potential indicates that many of them are functional stem cells. When hepatocyte-damaging agents also impair the regenerative ability of surviving hepatocytes, a potential stem cell system of biliary origin is activated to generate new hepatocytes - a reversal of ontogeny. Now both bile duct derived cells and hepatocytes can be isolated from the liver, genetically modified in vitro and returned to their in vivo origins where, after considerable population expansion, they can function as hepatocytes - paving the way for ex vivo gene therapy.

PMID:
9914178
DOI:
10.1016/s0955-0674(98)80111-7
[Indexed for MEDLINE]

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