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Curr Opin Cell Biol. 1998 Dec;10(6):716-20.

Recent progress in identifying genes regulating hematopoietic stem cell function and fate.

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  • 1Blood and Marrow Transplantation Program Markey Cancer Center University of Kentucky Medical Center 800 Rose Street Room CC405 Lexington KY 40536 USA.


Significant advances in the use of genetic and molecular biology strategies have recently begun to identify genes that have a major impact on the determination, commitment and developmental potential of hematopoietic stem cells. Using a variety of experimental strategies, genes such as SCL, GATA-2, HoxB4, Flk-2, c-mpl, dlk, and others have been implicated as important regulators of stem cell growth. In addition, genetic mapping has identified several loci that correlate strongly with stem cell numbers and proliferation.

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