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Curr Opin Cell Biol. 1998 Dec;10(6):721-6.

Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells.

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1
Leukaemia Research Fund Unit Department of Biomolecular Sciences University of Manchester Institute of Science and Technology PO Box 88 Sackville Street Manchester M60 1QD UK. A.Whetton@umist.ac.uk

Abstract

The understanding of molecular mechanisms regulating the formation, growth and differentiation of haemopoietic stem cells has advanced considerably recently. Particular progress has been made in defining the cytokines, chemokines and extracellular matrix components which retain and maintain primitive haemopoietic cell populations in bone marrow. Furthermore, signal transduction pathways that are critical for haemopoiesis, both in vivo and in vitro, and that are activated by cytokines have also been identified and further characterised. The importance of these processes has, this year, been exemplified by the phenotypes of mice deficient in key signal transduction proteins and the discovery that mutations in the component proteins of some signalling pathways are linked to human diseases. Significant advances in understanding the molecular mechanisms for mobilisation of stem cells from bone marrow have also been made this year; this has potential importance for bone marrow transplantation.

PMID:
9914176
[Indexed for MEDLINE]
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