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JAMA. 1976 Oct 11;236(15):1711-2.

Tricyclic antidepressants. Prolonged plasma levels after overdose.

Abstract

Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels greater than or equal to 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml. Patients ingesting substantial tricyclic overdoses may remain medically unstable for days. When high tricyclic levels persist, accurate psychiatric assessment is often impossible.

PMID:
989517
DOI:
10.1001/jama.236.15.1711
[Indexed for MEDLINE]

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