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Am J Psychiatry. 1999 Jan;156(1):145-7.

Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia.

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1
Department of Psychiatry, University of California, Irvine 92697, USA.

Abstract

OBJECTIVE:

The focus of this study was the systematic evaluation of the clinical effects of glycine as an adjunct to the atypical antipsychotic clozapine in the treatment of schizophrenia.

METHOD:

In a double-blind, placebo-controlled study, 19 patients with chronic, treatment-resistant schizophrenia who were maintained on optimal doses of clozapine (400-1200 mg/day) were administered either 30 g/day of glycine (N=9) or placebo (N=10) for 12 weeks. Clinical evaluations with the Brief Psychiatric Rating Scale, the Scale for the Assessment of Negative Symptoms, and the Simpson-Angus movement scale were completed biweekly.

RESULTS:

The use of glycine as an adjunct to clozapine was not effective in decreasing positive or negative symptoms. In contrast, the patients treated with clozapine without glycine had a 35% reduction in positive symptoms.

CONCLUSIONS:

These preliminary data suggest that glycine may interfere with the antipsychotic efficacy of atypical neuroleptics such as clozapine.

PMID:
9892314
DOI:
10.1176/ajp.156.1.145
[Indexed for MEDLINE]
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