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Anticancer Res. 1998 Nov-Dec;18(6B):4769-76.

Prognostic factors in head and neck oncology: a critical appraisal for use in clinical practice.

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  • 1Head and Neck Unit, European Institute of Oncology, Milan, Italy. fchiesa@ieo.it

Abstract

BACKGROUND:

An ideal prognostic factor would provide information about the biological behaviour of a tumour, permitting the prediction of the outcome and response to therapy. Nowadays there is a considerable confusion concerning the value, significance and use of the know prognostic factors in head and neck cancer.

MATERIAL AND METHODS:

A meta-analysis of works published in literature between 1993 and August 1997 on prognostic factors in head and neck oncology was carried out.

RESULTS:

Prognostic factors were analysed and classified according to Wennenberg in the following groups: patient-related factors, tumour-related factors and factors predicting response to therapy.

CONCLUSIONS:

We propose a classification of prognostic factors in head and neck cancer according to their significance and reliability: factors of proven significance and experimental factors. This classification might be useful to select guidelines to use in clinical practice.

PMID:
9891555
[PubMed - indexed for MEDLINE]
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