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Eur Cytokine Netw. 1998 Dec;9(4):687-8.

TRAIL induces apoptosis and activation of NFkappaB.

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Universitätskinderklinik, Prittwitzstr. 42, 89075 Ulm, Germany. Tel: (+49) 731 5027700, Fax: (+49) 731 5026681, USA.


TRAIL (TNF-related-apoptosis-inducing-ligand) was found as a new member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. TRAIL induces two different signals, cell death mediated by caspases and gene induction mediated by NFkappaB. Inhibition of TRAIL-induced activation of NFkappaB augments apoptosis induction by TRAIL and attenuates apoptosis resistance.

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