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Curr Biol. 1998 Dec 17-31;8(25):R925-7.

DNA segregation: putting chromosomes in their place.

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  • 1Department of Molecular Biology and Microbiology, Tufts University Health Science Campus, Boston, Massachusetts 02111, USA.


Recent studies provide evidence that bacterial chromosomes are replicated by an enzyme factory, the replisome, located at a fixed position at the center of the cell; the fixed replisome could be a major factor in determining chromosome order in the cell, and may provide the force that drives chromosome segregation.

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