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Curr Biol. 1998 Dec 17-31;8(25):R931-3.

Sex chromosomes: evolving dosage compensation.

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Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 2BR, UK.


Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.

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