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J Am Soc Mass Spectrom. 1999 Jan;10(1):27-34.

Matrix-assisted laser desorption/ionization mass spectra reflect solution-phase zinc finger peptide complexation.

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1
Laboratory of Organic Chemistry, ETH Z├╝rich, Switzerland.

Abstract

The complexation between an 18-residue zinc finger peptide of CCHC type (CCHC = Cys-X2-Cys-X4-His-X4-Cys, X = variable amino acid) from the gag protein p55 of human immunodeficiency virus type 1 (HIV-1) and various transition metal ions was studied by means of circular dichroism spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). A correlation between the complexation behavior in solution and in MALDI-MS could be established. It was shown that MALDI-MS is a fast method suitable for studying metal binding properties of zinc finger complexes.

PMID:
9888182
DOI:
10.1016/S1044-0305(98)00116-0
[Indexed for MEDLINE]
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