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Acta Physiol Scand. 1998 Dec;164(4):457-69.

Role of tyrosine phosphorylation in excitation-contraction coupling in vascular smooth muscle.

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National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, St Mary's Hospital, London, UK.


Increasingly it is recognized that tyrosine phosphorylation plays an important part in the regulation of function in differentiated contractile vascular smooth muscle. Tyrosine kinases and phosphatases are present in large amounts in vascular smooth muscle and have been reported to influence a number of processes crucial to contraction, including ion channel gating, calcium homeostasis and sensitization of the contractile process to [Ca2+]i. This review summarizes current understanding regarding the role of tyrosine phosphorylation in excitation-contraction coupling in blood vessels.

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