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Mol Cell. 1998 Dec;2(6):863-7.

The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Author information

1
Howard Hughes Medical Institute, Pennsylvania State University, University Park 16802-4500, USA. pag9@psu.edu

Abstract

The SAGA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional regulators including Ada, Spt, and TAFII proteins. Here we identify an additional novel subunit of the complex, Tra1, an ATM/PI-3-kinase-related homolog of the human TRRAP cofactor, which is essential for c-Myc and E2F-mediated oncogenic transformation. Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. In addition, the Tra1 protein is a component of at least two other histone acetyltransferase protein complexes. These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter.

PMID:
9885573
[Indexed for MEDLINE]
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