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Pediatr Clin North Am. 1998 Oct;45(5):1137-55, ix.

The new antidepressants. Selective serotonin reuptake inhibitors.

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Division of Child and Adolescent Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.


This article provides a resource for choosing among available SSRIs to treat pediatric patients. SSRIs are addressed according to five areas of interest: treatment efficacy data, untoward effects profile, pharmacokinetic characteristics, potential drug-drug interactions, and cost. Strategies for SSRI dosing and pretreatment work-up are also discussed. Included in the article is a reference table for SSRI dosing, available preparations, and cost per dose. Also included is an abbreviated reference table of important cytochrome P-450 isoenzymes, isoenzyme inhibition by SSRIs, and selected psychotropic and somatic medication substrates.

[Indexed for MEDLINE]

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