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Arch Biochem Biophys. 1999 Jan 15;361(2):195-201.

Identification and cloning of rat galectin-2: expression is predominantly in epithelial cells of the stomach.

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Institute of Scientific and Industrial Research, Osaka University, Osaka, Ibaraki, 567-0047, Japan.


A complementary DNA clone preferentially expressed in the gastrointestinal tract was obtained from a rat stomach library. The protein coded by the clone had a single carbohydrate recognition domain having conserved motifs for beta-galactoside binding and showed 67% amino acid identity with human galectin-2. The recombinant protein synthesized in Escherichia coli could bind to an asialofetuin column and was eluted with beta-galactopyranoside. From these observations, we named the protein rat galectin-2 coded by the cDNA. The rat galectin-2 was predominantly expressed in the epithelial cells of stomach. Thus this protein may form a mucin layer cross-linking with the beta-galactoside moiety of glycoproteins.

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