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Aliment Pharmacol Ther. 1998 Dec;12(12):1225-30.

Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study.

Author information

1
Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan. ibd@med.kurume-u.ac.jp

Abstract

BACKGROUND:

Germinated barley foodstuff (GBF) has been shown to attenuate intestinal injury in animal models, largely by increasing luminal short-chain fatty acid production.

AIM:

To investigate the safety and efficacy of GBF in the treatment of ulcerative colitis (UC).

METHODS:

Ten patients with active UC received 30 g of GBF daily for 4 weeks in an open-label treatment protocol while the baseline anti-inflammatory therapy was continued. The response to treatment was evaluated clinically and endoscopically. Pre- and post-treatment stool concentrations of short-chain fatty acids were measured by gas-liquid chromatography.

RESULTS:

Patients showed improvement in their clinical activity index scores, with a significant decrease in the score from 6.9+/-1.4 to 2.8+/-1.5 (mean+/-S.E.M., P < 0.05). The endoscopic index score fell from 6.1+/-2.3 to 3.8+/-2.3 (P < 0.0001). Patients showed an increase in stool butyrate concentrations after GBF treatment (P < 0.05). No side-effects were observed.

CONCLUSIONS:

Oral GBF therapy may have a place in management of ulcerative colitis, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.

PMID:
9882030
[Indexed for MEDLINE]
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