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J Pediatr. 1999 Jan;134(1):103-6.

A cluster of microvillous inclusion disease in the Navajo population.

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1
Department of Pediatric Gastroenterology and Nutrition, Phoenix Children's Hospital, Phoenix, Arizona 85006, USA.

Abstract

We report 4 unrelated patients with characteristic microscopic findings of microvillous inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child with MID. The unusually high incidence in this population indicates that a founder effect might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It is recommended that all Navajo infants presenting with severe diarrhea during early infancy undergo investigation for MID.

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PMID:
9880458
DOI:
10.1016/s0022-3476(99)70380-x
[Indexed for MEDLINE]

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