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Peptides. 1998;19(10):1739-42.

Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice.

Author information

1
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

Abstract

There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U-shaped dose response. To determine whether the anxiolytic effect of motilin was mediated via motilin receptors in the brain, the effect of GM-109, a novel motilin receptor antagonist, was investigated. GM-109 showed a significant and dose-dependent antagonism on the motilin-induced anxiolytic effect. GM-109 administered alone had no effect on anxiety. These results suggest that motilin receptors are present in the brain and may have a role in anxiety and emotion.

PMID:
9880080
[Indexed for MEDLINE]

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