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Virology. 1998 Dec 20;252(2):373-5.

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.

Author information

1
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0720, USA. james.e.crowe@vanderbilt.edu

Abstract

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.

PMID:
9878616
DOI:
10.1006/viro.1998.9462
[Indexed for MEDLINE]
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