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Drug Dev Ind Pharm. 1998 Dec;24(12):1113-28.

Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers.

Author information

1
Pharmapeptides, Interuniversity Centre Geneva-Lyon, France.

Abstract

The techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed. Although there is abundant literature on this topic, only a few focus on the thorough analysis of preparative procedures. In particular, four techniques are discussed in terms of their technological advantages and drawbacks: emulsification evaporation, solvent displacement, salting-out, and emulsification diffusion. The proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective. The effects of preparative variables on nanoparticle size and drug-entrapment efficiency are also discussed.

PMID:
9876569
DOI:
10.3109/03639049809108571
[Indexed for MEDLINE]

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