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Arch Pharm Res. 1998 Aug;21(4):478-80.

Studies of structure activity relationship of flavonoids for the anti-allergic actions.

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College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.


The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.

[Indexed for MEDLINE]

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