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Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):185-90.

A two-step, two-signal model for the primary activation of precursor helper T cells.

Author information

1
Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5 Canada. bretschr@duke.usak.ca

Abstract

I present here a new model for the primary activation of precursor helper T cells. Observations demonstrate that the immune system learns not to respond to extrathymic, organ-specific self-antigens because of their early appearance in development. The immune system thus discriminates between peripheral self-antigens and foreign antigens and, when mature, usually makes an immune response against only the latter. Contemporary models for the activation and inactivation of T helper (Th) function do not account for such discrimination. The model proposed here is consistent with contemporary findings and incorporates a mechanism of peripheral self-nonself discrimination.

PMID:
9874793
PMCID:
PMC15114
[Indexed for MEDLINE]
Free PMC Article

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