10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties

K Müller; K Breu

doi:10.1016/s0960-894x(98)00580-0

10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3211-6. doi: 10.1016/s0960-894x(98)00580-0.

Authors

K Müller¹, K Breu

Affiliation

¹ Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität Münster, Germany. kmuller@uni-muenster.de

PMID: 9873705
DOI: 10.1016/s0960-894x(98)00580-0

Abstract

Work aimed at further improving the benefit to risk ratio of the antipsoriatic agent anthralin has led to 10-omega-phenylalkyl-9(10H)-anthracenones, members of which are equally potent as inhibitors of the growth of HaCaT keratinocytes. In contrast to anthralin, induction of membrane injury is strongly reduced as documented by the release of LDH activity from cytoplasm of keratinocytes.

MeSH terms

Administration, Topical
Anthralin / analogs & derivatives*
Anti-Inflammatory Agents / pharmacology*
Cell Division / drug effects
Cell Line
Cell Membrane / drug effects
Growth Inhibitors / pharmacology*
Humans
Hydroxyl Radical
Keratinocytes / drug effects*
L-Lactate Dehydrogenase / metabolism
Psoriasis / drug therapy*
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Growth Inhibitors
Hydroxyl Radical
L-Lactate Dehydrogenase
Anthralin