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Bioorg Med Chem Lett. 1998 Nov 17;8(22):3207-10.

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Author information

1
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.

Abstract

5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.

PMID:
9873704
[Indexed for MEDLINE]

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