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Bioorg Med Chem Lett. 1998 Oct 20;8(20):2931-6.

Pyrrolnitrin and related pyrroles endowed with antibacterial activities against Mycobacterium tuberculosis.

Author information

1
Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy.

Abstract

During development of nitroheterocycles with potential antimycobacterial activities we have tested against Mycobacterium tuberculosis a number of pyrroles strictly related to pyrrolnitrin, an antifungal antibiotic isolated from Streptomyces pyrrocinia. Some of the tested arylpyrrole derivatives and pyrrolnitrin have shown appreciable inhibiting activity against M. tuberculosis and M. avium. SAR studies well correlate antimycobacterial potency with the presence of halogens in the phenyl ring and a nitro group at position 3 of pyrrole.

PMID:
9873650
DOI:
10.1016/s0960-894x(98)00526-5
[Indexed for MEDLINE]

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