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Bioorg Med Chem Lett. 1998 Oct 6;8(19):2809-12.

Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.

Author information

1
Department of Chemistry, University of Michigan, Ann Arbor 48109, USA.

Abstract

The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec-1M-1.

PMID:
9873627
[Indexed for MEDLINE]

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