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Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8.

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Neurogen Corporation, Branford, CT 06405, USA.

Abstract

N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.

PMID:
9873609
DOI:
10.1016/s0960-894x(98)00469-7
[Indexed for MEDLINE]

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